Those who have very fair skin have a genetic predisposition towards sensitive skin. This could be caused by the lower amount of pigment and thinner epidermal layer. People with sensitive skin have more histamine readily produced in the body. The result is a more hypersensitive skin, waiting to react at any opportunity. Sensitized skin is not caused by genetic predisposition. It can affect anyone, any age of any race who is exposed to environmental assults. This can be in the form of UV light, pollution, or even extreme weather.